PATHOLOGY & BIOCHEMISTRY MODEL DEGREE EXAM QUESTIONS Coursework

PATHOLOGY & BIOCHEMISTRY MODEL DEGREE EXAM QUESTIONS - Coursework Example (write about 250 words) The identifying characteristic of malignant neoplasms, with nomenclature of either carcinoma or sarcoma in their suffixes, is that they have ill-defined borders, and are able to infiltrate surrounding tissues and metastasize to other tissues of the body. Malignant tumors are also more prone to necrosis and hemorrhage, as compared to benign ones, growth named with an –oma attached at the end. As such, surgical treatment alone is not enough in treating the disease. Adjunct therapy may include radiation and chemotherapy. In contrast, benign neoplasms can be resolved through surgery because they are encapsulated and their growth is limited within the tissue of origin. Given these reasons, the prognosis of patients with malignant neoplasms is poorer than those with benign growths. Microscopic differences are also present. Malignant neoplasms are composed of cells with a higher mitotic activity compared to benign neoplasms. Thus, malignant tumors are typically larger than benign one s. They also look different from benign cells, which look like normal, differentiated cells, because they are undifferentiated and anaplastic, their nuclei are big and hyperchromatic and their shapes are irregular. The malignant cells of a tumor also vary in size and shape, as opposed to cells of a benign tumor which are isomorphic. Malignant cells also lose their polarity, resulting to disorganized growth. Benign tumor cells still have their polarity intact, thus they are still capable of organized growth. Cell derangement is not just limited to structure , but also to function. Malignant cells have an altered function already, as opposed to benign tumors that retain the function of the tissue of origin. Q2. Write about the sequence of events and processes of the pathogenesis of a typical carcinoma. You may use the flow diagram below as a guide: (write about 200 words) EVENTS AND PROCESSES IN THE DEVELOPMENT OF DUCTAL CARCINOMA IN BREASTS NORMAL Nonproliferative PROLIFERATIVE CHANG ES Caused by loss of growth inhibitory signals, increase in pro-growth signals, or decreased apoptosis DNA INSTABILITY AND ATYPICAL HYPERPLASIA Nuclear enlargement, irregularity and hyperchromasia as cells continue to proliferate HIGH GRADE DUCTAL CARCINOMA IN SITU Solid sheets of pleomorphic cells with hyperchromatism and necrosis Abrogation of the basement membrane, angiogenesis, stromal invasion HIGH GRADE INVASIVE CARCINOMA Cell mass with ill-defined borders A stepwise process is needed in the

The Overcoat - Nikolai Gogol Essay Example | Topics and Well Written Essays - 500 words

The Overcoat - Nikolai Gogol - Essay Example The portrayal of the protagonist supports the idea that environmental oppression impacts the individual, which may result in the formation of deviant behavioral patterns. Early in the work, the protagonist’s appearance is describes as ordinary and rather sallow, stating â€Å"There is nothing we can do about [the protagonist appearance], it is all the fault of the St. Petersburg climate† (Gogol 234). While this statement at surface value seems to refer to the weather, it closely parallels the bureaucratic climate that, much like the weather, is a large and dismal force that the protagonist feels powerless to alter. Even the name of the character, Akaky Akakyevich, closely resembles the Russian term ‘okakat’ meaning to smear with excrement, or the term ‘caca’, which is of Greek origin but refers to excrement in many modern languages (Paul 1). A parallel is drawn between the oppression of the bureaucratic system, wherein a designated rank oppress es societal classes, and the oppression of the individual by his personal designation, in this case the character’s given name. This is supported by in the text by statements such as â€Å"with us, rank is something that must be stated before anything else†, highlighting the oppressive qualities of personal designations, such as rank (Gogol 234). Oppression on many levels shapes the traits of the protagonist, suggesting that environmental influences are responsible for future deviant behavior. The protagonist at first negotiates a reality filled with oppression with acceptance; however, when his expectations are made higher by the prospect of a new overcoat, symbolic of a rise in the societal hierarchy, the character develops deviant personality traits, ultimately leading to his death and the wrath of his angry spirit. The author describes the Very Important Person as a character that